Expanding Treatment Windows: The Shift in Stroke Care Protocols

Stroke care is changing fast. Learn how new imaging, TNK, and AI tools like Synapse AI are expanding treatment windows—and saving more lives.

Stroke treatment is evolving beyond strict time limits, thanks to advanced imaging, Tenecteplase (TNK), and AI-driven tools like Sevaro’s Synapse AI. New guidelines allow for life-saving interventions up to 24 hours after stroke onset in select patients, based on tissue viability instead of time alone. TNK enables faster, simpler treatment with lower bleeding risk and cost.

Sevaro’s platform accelerates triage, automates data delivery, and connects neurologists in seconds—empowering hospitals to expand access, reduce transfers, and improve outcomes, especially in underserved areas.

Expanding Treatment Windows: The Shift in Stroke Care Protocols

For decades, stroke treatment protocols operated on a tight schedule. Patients had just 3 to 4.5 hours to receive thrombolytics like alteplase (tPA), and beyond that, options were limited. But stroke care is entering a new era, one where time still matters, but tissue matters more.

Thanks to new clinical research, evolving guidelines, and cutting-edge technology, hospitals are rethinking what’s possible when it comes to stroke treatment. Today, more patients are eligible for care than ever before, even outside the traditional windows.

And this shift is saving lives.

Why the Window Is Expanding

The phrase “time is brain” is still true, untreated strokes cause the death of 1.9 million neurons per minute. But with advancements in imaging, stroke teams are no longer bound by time alone. Instead of relying solely on when symptoms began, clinicians now look at what’s happening inside the brain in real time.

Using advanced imaging like CT perfusion and MRI DWI (diffusion-weighted imaging), providers can assess whether brain tissue is still salvageable. If it is, treatment can proceed—even 6, 12, or up to 24 hours after symptom onset in select cases.

This personalized approach allows more patients to receive life-saving treatments like mechanical thrombectomy or thrombolytic agents, expanding eligibility and improving outcomes.

The Role of TNK in Faster Treatment

One of the most exciting developments in stroke protocols is the growing adoption of Tenecteplase (TNK), a newer clot-busting drug recently approved by the FDA. TNK offers key advantages:

  • Faster administration with a single IV push instead of a 60-minute infusion
  • Longer half-life and easier dosing
  • Lower risk of bleeding in many cases
  • Significantly lower cost compared to alteplase

At Sevaro, we’ve been using TNK with stroke patients for over three years—and the results speak for themselves. Our partner hospitals have seen:

  • Faster treatment times
  • Lower bleeding rates
  • Streamlined protocols that reduce complexity and cost

How Technology Is Accelerating Change

Even with updated protocols, treatment is still a race against the clock. That’s why tools like Synapse AI and Sevaro OneCall™ exist to help hospitals act fast and make the most of every minute.

Our platform identifies stroke symptoms in real time, automates triage, and surfaces critical data like imaging results and patient eligibility within seconds. And by removing outdated call center bottlenecks, we connect hospitals to credentialed neurologists instantly—not after waiting on hold.

This is what modern stroke care looks like: faster triage, smarter decisions, and more patients getting the treatment they need—on time.

Why This Matters for Hospitals and Communities

Expanding the treatment window doesn’t just mean better outcomes, it means broader access. Many stroke patients, especially those in rural or underserved areas, don’t arrive within the traditional treatment window. Updated protocols supported by real-time technology allow these patients to receive care that would’ve been out of reach just a few years ago.

It also helps hospitals deliver more equitable care, reduce unnecessary transfers, and keep patients closer to home while still providing world-class treatment.

Looking Ahead

This is just the beginning. As AI and imaging technology continue to evolve, we’ll see even more personalized stroke care, where treatment decisions are based on a patient’s biology, not the hands of the clock.

At Sevaro, we’re proud to be part of that future. From faster diagnosis to smarter treatment pathways, we’re helping hospitals build systems that aren’t just reactive, they’re proactive, data-driven, and built for scale.

Because when it comes to stroke care, the right protocol at the right time can change everything.

📣 Help Us Spread the Word! Join Us in the Fight Against Stroke

At Sevaro, we’re driven by purpose and powered by speed—both on the track and in the hospital. Stroke care doesn’t have to be delayed, misunderstood, or scary. With the right tools and education, we can change the story.

So start with one small act:

  1. Send this blog post to your family, friends, and co-workers
  2. Order your copy of BEFAST: Be a Superhero
  3. Follow Sevaro and Donovan Strauss Racing on social media for live event coverage and stroke facts all month long
  4. Share the signs of stroke using #BEFAST and #StrokeAwarenessMonth

Together, we’ll help the world BEFAST.

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